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Intraosseous Injections

Injection under the cartilage, just below the joint
surface can dramatically improve outcomes.

Intraosseous Injections

For Advanced Joint Disease, Intraosseus Injections Of Bone Marrow Aspirate Concentrate Can Significantly Improve The Outcome Of Your Regenerative Medicine Procedure.

Intraosseous (io) Injections can be used to deliver regenerative substances directly into the bone below the joint surface. Intraosseous Injections are usually injected together with injections directly into the joint, multiplying the effect. This is a new and highly specialized injection technique.

In conditions like osteoarthritis, bone marrow aspirate concentrate which contain orthobiological cells can be delivered under Xray guidance intraosseously directly at the site of damage to help stimulate healing and regeneration.

Intraosseous Injections represent a new comprehensive approach targeting joint disease and osteoarthritis. Traditionally in most cases, regenerative medicine substances (such as bone marrow aspirate concentrate or PRP) are simply injected into the joint space where the patient is having issues. 

With Intraosseous Injections, the regenerative substances are also injected directly into the bone under the joint surface (the subchondral bone.)

When arthritis is more advanced, simply injecting into the joint will only address part of the problem: the environment inside the joint. It will not address the deeper layers below the joint surface. In areas of severe cartilage wear, the bone under the joint surface is also degenerated. It is thought that this bone under the joint, which has a poor blood supply, benefits from directly injecting autologous cells into it, to stimulate the body’s natural ability to kick start the repair process and alter cell signaling in these dysfunctional regions.

Combined Intraosseous Injections
and Intra articular injection

Benefits of Combined Intraosseous Injections and
Intra articular injection

Are intraosseous injections right for you? Talk to one of our patient educators now to find out.


i Role of Scaffolds, Subchondral, Intra-Articular Injections of Fresh Autologous Bone Marrow Concentrate Regenerative Cells in Treating Human Knee Cartilage Lesions: Different Approaches and Different Results; J Hernigou, P Vertongen , J Rasschaert and P Hernigou; Int. J. Mol. Sci. 2021, 22(8), 384 Link to Article
ii Effect of Combined Intraosseous and Intraarticular Infiltrations of Autologous Platelet-Rich Plasma on Subchondral Bone Marrow Mesenchymal Stromal Cells from Patients withHip Osteoarthritis; P Ganguly, N Fiz, M Beitia, H Owston, D Delgado, E Jones,and Mikel Sánchez; J. Clin. Med. 2022, 11(13), 3891, Link to Article
iii Mesenchymal stem cells for subchondral bone marrow lesions: From bench to bedside; RMPasculli, CD Kenyon, WA Berrigan, K Mautner, K Hammond, P Jayaram, Bone reports Vol 17, December 2022, 101630, Link to Article
iv Intraosseous Injections Are Safe And Effective in Knee Osteoarthritis: A Systematic Review; B Kaiji Betzler, YJ Chee, HR Bin Abd Razak; Arthroscopy, Sports, Medicine, And Rehabilitation, V3, Iss 5, E1557-E1567, Oct 2021, Link to Article

Our Treatments

Is Orthobiological Cell Treatment Right For You?

Although Orthobiologic Treatments are considered by some people to be experimental, various research studies show that cellular therapy and platelet rich plasma injections may provide excellent relief from joint and musculoskeletal pain and ongoing inflammation.

Conditions Treated


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